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Keywords: Hypermobility spectrum disorder, Ehlers-danlos syndrome, MTHFR Gene polymorphism, Folate deficiency, Hypermobility syndrome, Folate hypermobility List of Abbreviations 5-methylTHF 5-methyl tetrahydrofolate ASD Autism Spectrum Disorder ECM Extracellular Matrix EDS Ehlers-Danlos Syndrome FBPs Folate Binding Proteins FDHS Folate-Dependent Hypermobility Syndrome FRα Folate Receptor Alpha hEDS Hypermobile-type Ehlers-Danlos Syndrome HSD Hypermobility Spectrum Disorder MTHFR Methylenetetrahydrofolate reductase MMPs: Matrix Metalloproteinases PCFT Proton-Coupled Folate Transporter RFC Reduced Folate Carrier TGFβ Transforming Growth Factor β 1

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International Journal of Toxicology (2014) 11